From 2004 to 2005, George worked as a pharmacist for PPD. In 2006, he was the Inaugural VCU/ACCP/ASHP Healthcare Policy Fellow and worked in the HHS Office of the Assistant Secretary for Preparedness and Response, the personal office of a United States Senator, and in the government affairs offices of ASHP and ACCP. From 2007 to 2008, George worked at the Agency for Healthcare Research and Quality (AHRQ) on comparative effectiveness research programs and initiatives.

From 2008 to 2014, George worked at FDA, conducting regulatory science research, contributing to guidance development, and serving on new drug and biologic application review teams. He next worked as Medicaid Pharmacy Director for New Hampshire from 2014 to 2015, during which time he led the analysis and oversight of Medicaid pharmaceutical policies and quality improvement initiatives and served on a PCORI stakeholder review panel.

From 2015 to 2021, at MITRE, the Health/HHS Federally Funded Research and Development Center (FFRDC) operator, George served as a Principal in Health and Life Sciences, leading a staff of up to eight, and as a strategic advisor, researcher, and subject matter expert on CMS alternative payment models, HHS health and pharmaceutical policy, biomedical innovation, and health data-related projects and initiatives (e.g., NIH, AHRQ, HHS/ASPE projects), and innovative MITRE HIT and policy-related initiatives. Neyarapally rejoined HHS in February of 2021 at FDA in the Center for Drug Evaluation and Research (CDER).

Neyarapally received his B.S. in Finance from the University of Connecticut, Pharm.D. from the University of North Carolina, M.P.H. from the Johns Hopkins Bloomberg School of Public Health, and J.D. from the University of Maryland.